From the Florida Mainland:
Take the Florida Turnpike South to US1 South. Travel South on US1 to Key West.
When you reach Key West continue South on US1 / N. Roosevelt Avenue to Palm Avenue.
Turn Right onto Palm Avenue and travel over the bridge and around sharp curve to the left where Palm Avenue becomes Eaton Street.
From Eaton Street, turn Left onto William Street. Island City House Hotel is on the left at 411 William Street.